Sabin Strain Inactivated Polio Vaccine for the Polio Endgame

Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame

The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To achieve this aim, it is essential to block viral replication in individuals via induction of a robust mucosal immune response. Although it has long been recognized that inactivated poliovirus vaccine (IPV) is incapable of inducing a strong mucosal response on its own, it has recently become clear that IPV...

Universal use of inactivated polio vaccine.

OBJECTIVES To present an update on the status of poliomyelitis worldwide, number of cases per year, regions most affected by the disease, vaccines currently available, their risks and benefits, monovalent vaccine use, risks of disseminating a mutant virus in the community, progress that has been made in terms of worldwide eradication and the World Health Organization's (WHO) proposals in this t...

Perspectives on Introduction of Inactivated Poliovirus Vaccine in National Immunization Program and Polio Endgame Strategy

Preventing Vaccine-Derived Poliovirus Emergence during the Polio Endgame

Reversion and spread of vaccine-derived poliovirus (VDPV) to cause outbreaks of poliomyelitis is a rare outcome resulting from immunisation with the live-attenuated oral poliovirus vaccines (OPVs). Global withdrawal of all three OPV serotypes is therefore a key objective of the polio endgame strategic plan, starting with serotype 2 (OPV2) in April 2016. Supplementary immunisation activities (SI...

Introduction of Inactivated Poliovirus Vaccine in National Immunization Program and Polio Endgame Strategy.

The World Health Organization declared India among other 10 countries in South East Region - as 'polio-free' in 2014. Since then, the Government of India (GoI) has scaled up its initiatives against polio endgame which targets virus eradication and sequential withdrawal of type 2 virus from oral polio vaccine (OPV). However, prior to choosing the switch from trivalent OPV (t-OPV) to bivalent OPV...